The year 2019 in review

If 2018 was an important year with consolidation of CREAPHARM GROUP and opening of our first facility outside Europe, 2019 was made of a lot of successfull projects once again.



One step towards CREAPHARM GROUP’s growth: recruitment of our 200th collaborator early in the year! On 5 sites and allocated among Business Units CREAPHARM CLINICAL SUPPLIES, CREAPHARM INDUSTRY, CREAPHARM DISTRIBUTION and CREAPHARM COSMETICS, all work daily for our client satifaction! Among the numerous recruitments, a QA was appointed at CREAPHARM USA.


Strenghtening synergy between Business Units of CREAPHARM GROUP

That is in continuation with the CREAPHARM CLINICAL SUPPLIES services that CREAPHARM INDUSTRY supports Pharmas and Biotechs towards their health products commercialization. CREAPHARM INDUSTRY, known as a packaging expert for more than 40 years, provides them with an integrated solution including different high-value added services (


2019 Digitalisation & Dematerialization steps

  • Full-Traceability of packaging operations: CRISTAL software was extended to CREAPHARM CLINICAL SUPPLIES Reims
  • Electronic Batch Record was implemented in April at CREAPHARM CLINICAL SUPPLIES: the main advantages include relability, securization and environmental footprint reduction.
  • ERP CRISTAL 2 was deployed on CREAPHARM INDUSTRY: packing operations traceabilty is from now ensured by this software, including warehouse management system
  • Strong contribution to GS1 Group - Official Launch in March. As a pioneer in the DataMatrix use (in-house), CREAPHARM has been part of this group of experts for few years. Mission accomplished by the experts of the GS1 Clinical Trials Mission-Specific Work Group: a guideline was published to define the best practice identification and barcoding approach to be used for investigational medicinal products. Read here:


2019 Extension Works: always increasing capacities


4 GMP/GDP plants were expanded in 2019: CREAPHARM GROUP evolves, moves on, to serve Pharmas & Biotechs always better!



  • A new loading/unloading area was built
  • A new temperature-controlled storage room: this recently qualified 15-25°C warehouse has significantly increased our capabilities of experimental drug GDP storage.
  • A new cold room was added leading then to a 40% increase of the 2-8°C storage capacity on this plant. And it comes in addition to cold negative volumes (-20°C & -80°C) for Investigational Products storage



  • A new 2-8°C cold-chamber came in addition to the existing one to be able to store more and more cold IPs (more than 2-fold volume increase)
  • To undertake more projects, 2 new secondary packaging rooms, including one closed to the new cold chamber



  • Gaining a 50% increase of the total area, a 2-fold and 3-fold increase of 2-8°C and 15-25°C storage volume, respectively, CREAPHARM USA has continued to grow
  • 2 secondary packaging boxes were implemented: whereas CREAPHARM USA started last year its activities with only distribution management, it is now possible to trust them the clinical secondary packaging and labelling operations
    • The back-up generator system was strengthened
    • Completion of the return area building



    • One of the seven ISO8 packaging rooms was revamped for extended capacities



    • Storage capacity was doubled. This new area will enable to build new rooms in the future
    • A loading/unloading area was set-up
    • A dynamic storage was implemented
    • A common staff area was fitted for the team


    New Equipments


    • A new labelling machine was installed for ever more accurate clinical labelling of vials and syringes
    • Additional -80°C freezers were purchased on both Bordeaux and Atlanta sites. These ones are equiped with a twin independent Dual Cooling system, providing efficient ultra-low temperature cooling



      • By the investments made this year, CREAPHARM INDUSTRY has now 4 serialization & tamper-evident modules



      • A new complete line for liquid filling in bottles with a 1 mL minimum volume was set-up. CREAPHARM COSMETICS will now be able to meet request for sample manufacturing
      • A brand-new 150-300 kg reactor was purchased to maintain a state-of-the art machinery
      • A laboratory fume hood is now dedicated to raw material sampling


      New 2019 CREAPHARM Services & Products

      • Packaging - Serialization - As part of the application of the EU’s Falsified Medicines Directive (FMD), which started on February 9th, 2019, all concerned medication have to be serialized and equipped with a security seal (tamper evidence). Investments made, implementation completed, qualifications finished: since several months, CREAPHARM INDUSTRY’s team has been managing the product serialization of their clients. Serialization can be handled both on-line or off-line.


      • Packaging - Highly Potent Primary Packaging - A box adapted to most of cytotoxics, antibiotics and hormons has been built at CREAPHARM CLINICAL SUPPLIES Reims. It will be operational very shortly
      • Packaging - Clinical Packaging on dry ice - CREAPHARM CLINICAL SUPPLIES has made its packaging process evolve to be adapted to evey product, even innovant therapies to be kept at -80°C


      • Packaging – Sustainable Cosmetic Packs - If CREAPHARM COSMETICS has been engaged for over 10 years in the development of natural cosmetics, we did not wait for the explosion of Green Cosmetics to offer our partners formulas with a very high percentage of naturalness or even find them eco-responsible packaging solutions. In 2019, our purchasing manager has identified several innoative packs which were really appreciated by our customers, whatever the brand.


      • Distribution - CREAPHARM GREEN® Logistics: to serve its customers always better, CREAPHARM CLINICAL SUPPLIES has recently implemented a new solution for Clinical Distribution of your Investigational Products,
        REAPHARM GREEN® Logistics: Guaranteed - Robust - Ecofriendly - cost-Effective - Novel approach 
      • Formulation - CREAPHARM COSMETICS has developed its colour expertise. Our qualified team has implemented the pigment grinding in its processes
      • Formulation - Natural Origin Lip Cosmetics (Private Label) - Further to in-house formulation, a new line of Natural Origin Cosmetics has been launched by CREAPHARM COSMETICS, offering the opportunity to our clients to meet the consumer needs. It includes even a vegan nude Lipstick.


      BREXIT Issue

      • CREAPHARM CLINICAL SUPPLIES has supported numerous customers looking for a solution to be prepared to every BREXIT Scenario. Our Project Managers, with the support of our QA & Regulatory Affairs department, have proposed our EU QP-Release services to prevent any risk of supply disruption.
      • CREAPHARM INDUSTRY can also make its customers benefit from its marketed product release services.


      2019 Events


      2019 Audits

      • More than 30 customers came and audit the CREAPHARM GROUP different plants.
      • CREAPHARM COSMETICS was inspected in December and should get ISO 14385 certification very soon.
      • Our CREAPHARM CLINICAL SUPPLIES Bordeaux site was recently subject to a random inspection by the French Agency (ANSM). Everything was going well and we are waiting for the new certificates.



      CREAPHARM in the press in 2019


      • PharmaBoardRoom

      Read the full article

      • BFM Business TV

      As a guest of "L'Hebdo des PME" on BFM Business TV, a business broadcast dedicated to growing SMEs, Eric Placet, CEO of CREAPHARM GROUP, talked about the synergy between our Business Units.









      See in replay

      • Information Entreprises


      Read the full article

      • Magazine Reflets Actuels













      Read the full article



      And now?

      There is no doubt that we are not going to stop there!

      We invite you to follow both CREAPHARM’s Business Unit pages as well as and our CREAPHARM GROUP page on Linkedin to keep updated of our latest hot topics and projects.